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Glutamate AMPA receptor subunit 1 gene ( GRIA1 ) and DSM‐IV‐TR schizophrenia: A pilot case‐control association study in an Italian sample
Author(s) -
Magri Chiara,
Gardella Rita,
Barlati Stefano Davide,
Podavini Damiano,
Iatropoulos Paraskevas,
Bonomi Silvia,
Valsecchi Paolo,
Sacchetti Emilio,
Barlati Sergio
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30294
Subject(s) - ampa receptor , schizophrenia (object oriented programming) , glutamate receptor , association (psychology) , genetic association , protein subunit , psychology , receptor , psychiatry , medicine , gene , chemistry , genetics , biology , genotype , single nucleotide polymorphism , psychotherapist
Glutamatergic dysfunction is one of the major hypotheses for the pathogenesis of schizophrenia. The GRIA1 gene encodes for one (GluR1) of the four (GluR1–4) ionotropic AMPA receptor subunits. GRIA1 is a good candidate gene for susceptibility to schizophrenia since it maps in 5q33, a region where the presence of susceptibility loci has been suggested by independent genome‐wide scans and because its expression has been found to be decreased in the brain of some schizophrenia patients. We present data from a case‐control association study on the Italian population with eight polymorphisms spanning the whole GRIA1 gene. Single‐locus analysis revealed a significantly different allele distribution in cases and in controls of two SNPs (rs707176, 0.41 vs. 0.31, P = 0.009; rs2963944, 0.41 vs. 0.30, P = 0.007), and one microsatellite (rs10631988, allele 9: 0.40 vs. 0.29, P = 0.004). Haplotype analysis showed an increased frequency of a specific haplotype for these markers (C09CC, 0.39 vs. 0.28, P = 0.009). Therefore our data indicate that GRIA1 may be involved in susceptibility to DSM‐IV‐TR schizophrenia. © 2006 Wiley‐Liss, Inc.