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The effect of dopamine D2, D5 receptor and transporter (SLC6A3) polymorphisms on the cue‐elicited heroin craving in Chinese
Author(s) -
Li YiFeng,
Shao ChunHong,
Zhang Dandan,
Zhao Min,
Lin Ling,
Yan Pengrong,
Xie Yuying,
Jiang Kaida,
Jin Li
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30264
Subject(s) - craving , dopamine transporter , heroin , dopamine , addiction , psychology , dopamine receptor d2 , allele , dopamine receptor , medicine , psychiatry , genetics , neuroscience , biology , gene , drug , dopaminergic
Abstract Heroin dependence is resulted from the interaction between multiple genetic and environmental factors. Subjective craving is considered to be a central phenomenon, which contributes to the continuation of drug use in active abuser and the occurrence of relapse in detoxified abusers. Dopamine pathway has been implicated in the cue‐elicited craving for a variety of addictive substances. The objective of this study was to test the hypothesis that heroin addicts carrying specific variants in dopamine‐related genes would have higher levels of craving following exposure to a heroin‐related cue. Craving induced by a series of exposure to heroin‐related cue was assessed in a cohort of Chinese heroin abuser (n = 420) recruited from natural abstinence center at Shanghai. Significantly stronger cue‐elicited heroin craving was found in individuals carrying D2 dopamine receptor gene ( DRD2 ) TaqI RFLP A1 allele than the non‐carriers ( P < 0.001). Furthermore, we did not observed significant association of cue‐elicited craving with the nine‐repeat allelic variants in dopamine transporter gene ( DAT ) SLC6A3 and with the dinucleotide repeat polymorphism (DRP) 148bp allele in D5 dopamine receptor gene ( DRD5 ). The results of our study suggest that human dopamine pathway be involved in cue‐induced heroin craving, and indicate a potential genetic risk factor for persistent heroin behavior and relapse. © 2006 Wiley‐Liss, Inc.