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Hyperprolinemia is not associated with childhood onset schizophrenia
Author(s) -
Jacquet Hélène,
Rapoport Judith L.,
Hecketsweiler Bernadette,
Bobb Aaron,
Thibaut Florence,
Frébourg Thierry,
Campion Dominique
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30263
Subject(s) - missense mutation , schizoaffective disorder , schizophrenia (object oriented programming) , bipolar disorder , genetics , psychosis , psychology , gene , medicine , mutation , biology , psychiatry , cognition
In a previous report [Jacquet et al., 2005] we have shown that mild to moderate hyperprolinemia resulting from several alterations (either a complete deletion or missense mutations) of the proline dehydrogenase ( PRODH ) gene located on chromosome 22q11 is a risk factor for schizoaffective disorder but not for DSM3 R schizophrenia or bipolar disorder. We now report that hyperprolinemia is not associated with childhood onset schizophrenia (COS). © 2006 Wiley‐Liss, Inc.