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Prion genotypes in Central America suggest selection for the V129 allele
Author(s) -
Hardy John,
Scholz Sonja,
Evans Whitney,
Goldfarb Lev,
Singleton Andrew
Publication year - 2005
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30248
Subject(s) - allele , genotype , biology , locus (genetics) , allele frequency , genetics , selection (genetic algorithm) , evolutionary biology , gene , artificial intelligence , computer science
Using the well‐characterized, human diversity sample series, we show that the V129 prion allele has a very high frequency in South American populations relative to the East Asian populations from which it arose. We suggest there has been selection at the prion locus, possibly mediated by Kuru‐like diseases, which has influenced its allele frequency. © 2005 Wiley‐Liss, Inc.