Premium
Interindividual variation in anxiety response to amphetamine: Possible role for adenosine A 2A receptor gene variants
Author(s) -
Hohoff Christa,
McDonald Jennifer M.,
Baune Bernhard T.,
Cook Edwin H.,
Deckert Jürgen,
de Wit Harriet
Publication year - 2005
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30228
Subject(s) - adenosinergic , amphetamine , adenosine , adenosine receptor , dopamine , stimulant , dopamine receptor , receptor , medicine , psychology , pharmacology , endocrinology , biology , agonist
Amphetamine is thought to produce its stimulant effects mainly via the dopamine system, but its effects may also be influenced by other systems. Dopamine D 1 and D 2 receptors exist as heterodimers with adenosine A 1 and A 2A receptors, which modulate their responsiveness, suggesting that responses to amphetamine may also depend on adenosinergic function. We therefore studied the relevance of one adenosine A 1 and three adenosine A 2A receptor gene polymorphisms for the interindividual variability in amphetamine response in 99 healthy volunteers who received placebo or d‐amphetamine (10 or 20 mg). The 1976C/T and 2592C/T ins polymorphisms of the adenosine receptor gene were associated with increases in anxiety at both doses. This is consistent with recent observations indicating a role for adenosine A 2A receptor gene polymorphisms in anxiety. © 2005 Wiley‐Liss, Inc.