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Cytosolic PLA2 genes possibly contribute to the etiology of schizophrenia
Author(s) -
Tao Ran,
Yu Yaqin,
Zhang Xiaojuan,
Guo Yingjun,
Shi Jieping,
Zhang Xuan,
Xie Lin,
Liu Shuzheng,
Ju Guizhi,
Xu Qi,
Shen Yan,
Wei Jun
Publication year - 2005
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30210
Subject(s) - locus (genetics) , single nucleotide polymorphism , transmission disequilibrium test , allele , genotype , genetics , biology , genetic association , haplotype , gene
The present study detected three single nucleotide polymorphisms (SNPs), BanISNP at the PLA2G4A locus, rs1648833 at the PLA2G4B locus, and rs1549637 at the PLA2G4C locus, to investigate a genetic association between the cytosolic PLA2 (cPLA2) genes and schizophrenia. A total of 240 Chinese parent–offspring trios of Han descent were recruited for the genetic analysis. The transmission disequilibrium test (TDT) showed allelic association for rs1549637 (χ 2 = 5.68, uncorrected P = 0.017), but not for BanISNP and rs1648833. The conditioning on genotype (COG) test revealed a disease association for the BanISNP–rs1648833 combination (χ 2 = 12.54, df = 3, P = 0.0057) and for the BanISNP–rs1549637 combination (χ 2 = 9.72, df = 2, P = 0.021), but the conditioning on allele (COA) test did not show such an association for the above two combinations. Neither the COA test nor the COG showed a disease association for the rs1648833–rs1549637 combination. In the combination of all three SNPs, the COG test, but not the COA test, showed a strong association (χ 2 = 22.93, df = 6, P = 0.0008). These findings suggest that these three cPLA2 genes may all be involved in contributing to the etiology of schizophrenia although their effect size appears to be relatively small. © 2005 Wiley‐Liss, Inc.