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Family‐based association study of serotonin transporter gene polymorphisms in attention deficit hyperactivity disorder: No evidence for association in UK and Taiwanese samples
Author(s) -
Xu Xiaohui,
Mill Jonathan,
Chen ChiKen,
Brookes Keeley,
Taylor Eric,
Asherson Philip
Publication year - 2005
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30203
Subject(s) - allele , haplotype , genetics , serotonin transporter , biology , genetic association , variable number tandem repeat , genotype , attention deficit hyperactivity disorder , polymorphism (computer science) , gene , single nucleotide polymorphism , medicine , psychiatry
Five independent studies have reported associations between serotonin transporter gene ( 5 ‐ HTT ) polymorphisms and attention deficit hyperactivity disorder (ADHD). Four studies found evidence for association between the long‐allele of a 44‐base pair insertion/deletion polymorphism (5‐HTTLPR), one of the studies found association to a variable number tandem repeat within intron 2, another to the T‐allele of a single base pair substitution in the 3′‐untranslated regions and another reported preferential transmission of a haplotype of the three markers (long‐allele/10‐repeat‐allele/T‐allele). One further study found no evidence for these associations. We investigated the association of these three markers in two samples of ADHD patients from the United Kingdom (n = 197) and Taiwan (n = 212), using within‐family tests of association. No association was found between any of the three markers in either of the two populations. Although we found some evidence for the preferential transmission of a rare haplotype (long‐allele/9‐repeat‐allele/T‐allele; χ 2 = 4.5, P = 0.034), we concluded that this most likely occurred by chance factors alone. © 2005 Wiley‐Liss, Inc.