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Dihydropyrimidinase‐related protein 2 ( DRP‐2 ) gene and association to deficit and nondeficit schizophrenia
Author(s) -
Hong L. Elliot,
Wonodi Ikwunga,
Avila Matthew T.,
Buchanan Robert W.,
McMahon Robert P.,
Mitchell Braxton D.,
Stine O. Colin,
Carpenter William T.,
Thaker Gunvant K.
Publication year - 2005
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30181
Subject(s) - allele , allele frequency , schizophrenia (object oriented programming) , polymorphism (computer science) , medicine , genetics , gene , biology , psychiatry
A previous study has shown an association between the *2236T > C allele polymorphism of the dihydropyrimidinase‐related protein 2 ( DRP‐2 ) gene and schizophrenia in a Japanese sample [Nakata et al. (2003); Biological Psychiatry 53:571–576]. DRP‐2 is an important molecule in guiding neuronal development and its gene is located in 8p21, a chromosomal region that was previously shown to have significant linkage to schizophrenia and to several deficit symptoms of schizophrenia. We compared the frequency of the DRP‐2 *2236T > C polymorphism between subjects with (n = 117) and without (n = 72) schizophrenia, and then further evaluated whether the association was specific for the deficit (n = 24) and nondeficit (n = 93) forms of schizophrenia. In both Caucasians and African‐Americans, the C allele occurred more frequently in schizophrenia cases than controls, with this difference achieving statistical significance in Caucasians (C allele frequency: 42.0% in cases vs. 25.0% in controls, P = 0.014) but not African Americans (52.6% in cases vs. 50.0% in controls, P = 0.93). In Caucasians, the frequency of the C allele was significantly higher in both the deficit (allele frequency 53.3%, P = 0.009) and nondeficit (39.2%, P =0.050) forms of schizophrenia compared to controls (allele frequency 25.0%). We conclude that the DRP‐2 *2236 C allele may mark another polymorphism in DRP‐2 , or in a nearby gene, that may influence susceptibility to schizophrenia. © 2005 Wiley‐Liss, Inc.