Premium
Association between BDNF val 66 met genotype and episodic memory
Author(s) -
Dempster Emma,
Toulopoulou Timothea,
McDonald Colm,
Bramon Elvira,
Walshe Muriel,
Filbey Francesca,
Wickham Harvey,
Sham Pak C.,
Murray Robin M.,
Collier David A.
Publication year - 2005
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30150
Subject(s) - episodic memory , psychology , wechsler adult intelligence scale , brain derived neurotrophic factor , genotype , logical address , polymorphism (computer science) , allele , neurotrophic factors , medicine , psychiatry , cognition , genetics , biology , gene , receptor , overlay , physical address , computer science , programming language
The val 66 met polymorphism of brain derived neurotrophic factor (BDNF) has been associated with variability in episodic memory [Egan et al., 2003]. In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val 66 met polymorphism. We analyzed the effect of this polymorphism on episodic memory using the Wechsler Memory Scale, revised version (WMS‐R) by regression analysis between the WMS delayed score of logical memory and genotype (corrected for age, sex, and IQ). We found the met 66 allele conferred a lower score on the WMS delayed measure (R 2 = 0.014 P = 0.09), which was not significant. When cases and unaffected relatives were analyzed separately, met 66 was associated with a lower score on the WMS delayed measure in the relatives only (R 2 = 0.077 P = 0.01), which is consistent with previous findings. © 2005 Wiley‐Liss, Inc.