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Familial aggregation of schizophrenia‐spectrum disorders and obsessive‐compulsive associated disorders in schizophrenia probands with and without OCD
Author(s) -
Poyurovsky Michael,
Kriss Victoria,
Weisman Gregory,
Faragian Sarit,
Schneidman Michael,
Fuchs Camil,
Weizman Abraham,
Weizman Ronit
Publication year - 2005
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30148
Subject(s) - proband , schizophrenia (object oriented programming) , psychiatry , schizophrenia spectrum , psychology , first degree relatives , clinical psychology , family history , mood disorders , personality disorders , psychosis , medicine , personality , anxiety , social psychology , biochemistry , chemistry , mutation , gene
A substantial proportion of schizophrenia patients also has obsessive‐compulsive disorder (OCD). To further validate the clinical validity of a schizo‐obsessive diagnostic entity, we assessed morbid risks for schizophrenia‐spectrum disorders and OC‐associated disorders in first‐degree relatives of schizophrenia probands with and without OCD. Two groups of schizophrenia probands [with OCD (n = 57) and without OCD (n = 60)] and community‐based controls (n = 50) were recruited. One hundred eighty two first‐degree relatives of probands with OCD‐schizophrenia, 210 relatives of non‐OCD schizophrenia probands, and 165 relatives of community subjects were interviewed directly [59.3% (108/182), 51.9% (109/210), and 54.5% (90/165), respectively], using the Structured Clinical Interview for Axis‐I DSM‐IV Disorders and Axis II DSM‐III‐R Personality Disorders and the remaining relatives were interviewed indirectly, using the Family History Research Diagnostic Criteria. Relatives of OCD‐schiozphrenia probands had significantly higher morbid risks for OCD‐schizophrenia (2.2% vs. 0%; P = 0.033) and OCPD (7.14% vs. 1.90%; P = 0.014), and a trend towards higher morbid risk for OCD (4.41% vs. 1.43%; P = 0.08) compared to relatives of non‐OCD schizophrenia probands. When morbid risks for OCD, OCPD, and OCD‐schizophrenia were pooled together, the significant between‐group difference became robust (13.74% vs. 3.33%; P = 0.0002). In contrast, relatives of the two schizophrenia groups did not differ significantly in morbid risks for schizophrenia‐spectrum disorders, mood disorders, or substance abuse disorders. A differential aggregation of OC‐associated disorders in relatives of OCD‐schizophrenia versus non‐OCD schizophrenia probands, provides further support for the validity of a putative OCD‐schizophrenia (“schizo‐obsessive”) diagnostic entity. © 2004 Wiley‐Liss, Inc.