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Linkage disequilibrium analysis in the LOC93081‐KDELC1‐BIVM region on 13q in bipolar disorder
Author(s) -
Ferraren Dilberto O.,
Liu Chunyu,
Badner Judith A.,
Corona Winston,
Rezvani Azadeh,
Monje Virginia D.,
Gershon Elliot S.,
Bonner Tom I.,
DeteraWadleigh Sevilla D.
Publication year - 2005
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30121
Subject(s) - linkage disequilibrium , single nucleotide polymorphism , genetics , haplotype , biology , genetic linkage , bipolar disorder , locus (genetics) , genetic association , linkage (software) , allele , genotype , gene , neuroscience , cognition
Genome‐wide scans in bipolar disorder and a meta analysis on published data have provided evidence for linkage to chromosome 13q, although the reported peaks from various studies have not converged in a narrow region. Recently, single nucleotide polymorphisms (SNPs) at the G72/G30 locus have been shown to be associated with bipolar disorder suggesting its potential role in increasing disease risk. The proposed linkage region on 13q extends over a wide span, and could provide a clue to the existence of other susceptibility variants. In the present study, SNPs in the LOC93081‐KDELC1‐BIVM, a region proximal to G72, were interrogated in two bipolar family series. KDELC1 has a predicted filamin domain and BIVM contains an immunoglobulin‐like motif. The small pedigree series yielded a nominally significant global P ‐value due to under‐transmission of a rare haplotype but this finding was not supported by results from the larger series and in the case‐control study that compared 278 cases and 277 controls. © 2004 Wiley‐Liss, Inc.