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5‐HT 1A polymorphism and self‐transcendence in mood disorders
Author(s) -
Lorenzi Cristina,
Serretti Alessandro,
Mandelli Laura,
Tubazio Viviana,
Ploia Cristina,
Smeraldi Enrico
Publication year - 2005
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30111
Subject(s) - temperament and character inventory , self transcendence , temperament , psychology , mood , trait , serotonergic , transcendence (philosophy) , serotonin , clinical psychology , developmental psychology , personality , medicine , big five personality traits , psychoanalysis , receptor , theology , philosophy , computer science , big five personality traits and culture , programming language
Recently, an association between serotonin 1A receptor binding potential and self‐transcendence scores at the temperament and character inventory (TCI) has been reported. We tested involvement of 5‐HT 1A gene in this trait, in a sample of 40 remitted mood disorder patients. Subjects with the 5‐HT 1A *C/C genotype showed significantly lower scores at the total self‐transcendence and at the sub‐scales of transpersonal identification and spiritual acceptance. Our preliminary results further support the involvement of the serotoninergic pattern in the self‐transcendence character trait. © 2005 Wiley‐Liss, Inc.