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Association analysis of NOTCH 4 polymorphisms with schizophrenia among two independent family based samples
Author(s) -
Prasad S.,
Chowdari K.V.,
Wood J.,
Bhatia T.,
Deshpande S.N.,
Nimgaonkar V.L.,
Thelma B.K.
Publication year - 2004
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30083
Subject(s) - locus (genetics) , single nucleotide polymorphism , genetic association , genetics , schizophrenia (object oriented programming) , polymorphism (computer science) , association (psychology) , biology , gene , medicine , allele , psychology , genotype , psychiatry , psychotherapist
The present study investigated polymorphisms of the NOTCH 4 gene in two independent samples from India and USA, consisting of patients with schizophrenia and their parents (n = 182, and n = 148 ‘trios,’ respectively). Five DNA markers, namely (GAAG) n , (TAA) n , SNP1, SNP2, and (CTG) n were evaluated. Transmission distortion, consistent with a modest association was detected among both samples. Additional association studies at this locus are warranted. © 2004 Wiley‐Liss, Inc.