Association analysis of  NOTCH 4  polymorphisms with schizophrenia among two independent family based samples | Zendy

Prasad S. | Zendy; Chowdari K.V. | Zendy; Wood J. | Zendy; Bhatia T. | Zendy; Deshpande S.N. | Zendy; Nimgaonkar V.L. | Zendy; Thelma B.K. | Zendy

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Association analysis of NOTCH 4 polymorphisms with schizophrenia among two independent family based samples

Author(s) -

Prasad S.,

Chowdari K.V.,

Wood J.,

Bhatia T.,

Deshpande S.N.,

Nimgaonkar V.L.,

Thelma B.K.

Publication year - 2004

Publication title -

american journal of medical genetics part b: neuropsychiatric genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.393

H-Index - 126

eISSN - 1552-485X

pISSN - 1552-4841

DOI - 10.1002/ajmg.b.30083

Subject(s) - locus (genetics) , single nucleotide polymorphism , genetic association , genetics , schizophrenia (object oriented programming) , polymorphism (computer science) , association (psychology) , biology , gene , medicine , allele , psychology , genotype , psychiatry , psychotherapist

The present study investigated polymorphisms of the NOTCH 4 gene in two independent samples from India and USA, consisting of patients with schizophrenia and their parents (n = 182, and n = 148 ‘trios,’ respectively). Five DNA markers, namely (GAAG) n , (TAA) n , SNP1, SNP2, and (CTG) n were evaluated. Transmission distortion, consistent with a modest association was detected among both samples. Additional association studies at this locus are warranted. © 2004 Wiley‐Liss, Inc.

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