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Phenotype studies of the DRD4 gene polymorphisms in ADHD: Association with oppositional defiant disorder and positive family history
Author(s) -
Kirley Aiveen,
Lowe Naomi,
Mullins Celine,
McCarron Mary,
Daly Grainne,
Waldman Irwin,
Fitzgerald Michael,
Gill Michael,
Hawi Ziarih
Publication year - 2004
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30072
Subject(s) - allele , family history , attention deficit hyperactivity disorder , genetic association , heritability , genetics , medicine , association (psychology) , polymorphism (computer science) , genotype , psychiatry , psychology , gene , biology , single nucleotide polymorphism , psychotherapist
The objective of this study was to investigate association of DRD4 polymorphisms with ADHD subtypes for which there is evidence for increased heritability. The genetic variants tested were the 120 bp insertion/deletion, the −616, −521, −376, and the 48 bp DRD4 VNTR. The primary analyses were of association with oppositional defiant disorder (ODD), conduct disorder (CD), and diagnostic subtypes. Secondary analyses of clinical subtype were exploratory in nature and included analysis of association of DRD4 polymorphisms with family history of ADHD. We observed significant association between DRD4 7‐repeat allele transmission and ADHD children with comorbid ODD (χ 2 = 6.74, df = 1, P = 0.01, OR = 2.45) The DRD4 7‐repeat allele was also significantly associated with family history positive ADHD (χ 2 = 10.12, df = 1, P = 0.0021, OR = 3.57). We observed no significant distortion in the transmission of any of the tested DRD4 variants with inattentive or hyperactive‐impulsive subtypes or symptom dimensions. In conclusion, our findings of increased DRD4 7‐repeat allele transmission in ODD extend those reported by Holmes et al. [2002: Am J Med Genet Neuropsychiatr 114:150–153]. To our knowledge, this is the first study to report association of the DRD4 7‐repeat allele with ADHD children who have a positive family history of ADHD. Overall, the results from this study support the investigation of clinical subtypes in molecular genetic studies of ADHD. © 2004 Wiley‐Liss, Inc.