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Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5‐HT1Dα and 5‐HT1Dβ autoreceptor genes: Family‐based association study
Author(s) -
Ambrósio Alda M.,
Kennedy James L.,
Macciardi Fabio,
Coelho Isabel,
Soares Maria J.,
Oliveira Catarina R.,
Pato Carlos N.
Publication year - 2004
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30023
Subject(s) - linkage disequilibrium , transmission disequilibrium test , disequilibrium , taqi , haplotype , genetic association , genetics , population , autoreceptor , biology , psychology , allele , polymorphism (computer science) , gene , medicine , receptor , genotype , single nucleotide polymorphism , environmental health , ophthalmology , serotonin
Genetic factors play a major role in the etiology of schizophrenia and disturbances of serotonergic pathways have been implicated in this disorder. The aim of the present study was to examine genetic association between schizophrenia and polymorphisms in the 5‐HT1Dα (TaqI) and 5‐HT1Dβ (T261G and G861C) autoreceptor genes in ninety trios from Portugal. No association or linkage disequilibrium was obtained between schizophrenia and 5‐HT1Dα and 5‐HT1Dβ autoreceptor genes with both haplotype relative risk (HRR) and transmission disequilibrium test (TDT). Concerning 5‐HT1Dβ autoreceptor gene, also negative results was obtained in the analysis of the haplotypes with transmit. Thus, our data provide no support for the hypothesis that polymorphisms at 5‐HT1Dα (TaqI) and 5‐HT1Dβ (T261G and G861C) genes contributes to susceptibility to schizophrenia in the Portuguese population. © 2004 Wiley‐Liss, Inc.