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Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia
Author(s) -
Zammit Stanley,
Jones Gaynor,
Jones Susan J.,
Norton Nadine,
Sanders Robert D.,
Milham Charis,
McCarthy Geraldine M.,
Jones Lisa A.,
Cardno Alastair G.,
Gray Marion,
Murphy Kieran C.,
O'Donovan Michael C.,
Owen Michael J.
Publication year - 2004
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30021
Subject(s) - monoamine oxidase a , catechol o methyl transferase , schizophrenia (object oriented programming) , genetics , aggression , psychology , epistasis , genotype , monoamine oxidase b , clinical psychology , biology , gene , psychiatry , monoamine oxidase , enzyme , biochemistry , receptor , serotonin
Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined the relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well‐powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior. © 2004 Wiley‐Liss, Inc.