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Serotonin 1B (5HT‐1B) receptor polymorphism (G861C) in suicide victims: Association studies in German and Slavic population
Author(s) -
Stefulj Jasminka,
Büttner Andreas,
Skavic Josip,
Zill Peter,
Balija Melita,
Eisenmenger Wolfgang,
Bondy Brigitta,
Jernej Branimir
Publication year - 2004
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.20174
Subject(s) - impulsivity , allele , 5 ht receptor , genotype , german , population , serotonergic , psychology , medicine , psychiatry , serotonin , genetics , biology , receptor , gene , history , environmental health , archaeology
Serotonergic dysfunction is believed to be involved in the susceptibility to suicide due to functional alternations in the serotonin‐related genes. Serotonin 1B (5HT‐1B) receptor mediates aggressive behavior in mice models and was proposed to be involved in the control of aggression and impulsivity in humans. In this study we have investigated the association of G861C polymorphism of the 5HT‐1B receptor gene with suicide commitment. Study was based on two independent samples, one of German (245 suicide victims vs. 248 controls) and the other of Slavic/Croatian (118 suicide victims vs. 192 controls) ethnicity. No significant differences in allele or genotype frequencies between victims and controls were demonstrated either in German or Croatian sample. There were no differences in allele frequencies between German and Croatian population, and the combined sample, having high statistical power, also did not demonstrate significant differences between victims and controls. Results provide evidence that the investigated 5HT‐1B receptor gene variants are not implicated in the susceptibility to suicide. © 2004 Wiley‐Liss, Inc.