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Direct analysis of the genes encoding G proteins Gα T2 , Gα o , Gα Z in ADHD
Author(s) -
Turic D.,
Langley K.,
Kirov G.,
Owen M.J.,
Thapar A.,
O'Donovan M.C.
Publication year - 2004
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.20173
Subject(s) - gene , genetics , exon , genotyping , biology , genotype
We have followed up the extensive replicated evidence that the dopamine DRD4 receptor is involved in the aetiology of ADHD by undertaking direct analysis of genes encoding other proteins in this effector system. We prioritised the genes encoding G protein α subunits Gα T2 , Gα o , Gα Z as these have been shown to transduce the effects of ligand binding at DRD4. We screened the exons of all three genes for sequence variation in 28 unrelated subjects with ADHD and identified 13 novel polymorphisms. All were tested for possible association with ADHD using a combination of pooled and individual genotyping. The results of our study do not suggest that polymorphisms in these genes contribute to susceptibility to ADHD. © 2004 Wiley‐Liss, Inc.