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Adrenergic alpha 2C receptor genomic organization: Association study in adult ADHD
Author(s) -
De Luca Vincenzo,
Muglia Pierandrea,
Vincent John B.,
Lanktree Matthew,
Jain Umesh,
Kennedy James L.
Publication year - 2004
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.20171
Subject(s) - linkage disequilibrium , transmission disequilibrium test , atomoxetine , proband , attention deficit hyperactivity disorder , allele , genetics , locus (genetics) , psychology , medicine , psychiatry , biology , gene , haplotype , methylphenidate , mutation
Attention deficit hyperactivity disorder (ADHD) is a chronic psychiatric condition in children and follow up studies have indicated that one to two thirds of patients continue to suffer from ADHD during late adolescence and adulthood. Pharmacological interventions, such as the new selective noradrenergic reuptake inhibitor, atomoxetine, suggest the adrenergic system as candidate in ADHD. We examined for the presence of linkage disequilibrium between the alpha 2C adrenergic receptor (ADRA2C) microsatellite polymorphism upstream of the ADRA2C gene and adult ADHD in a sample of nuclear families. We also present new information on the genomic organization of the ADRA2C locus. The microsatellite polymorphism was typed in 128 small families and analyzed using the Transmission Disequilibrium Test (TDT). There was no preferential transmission of any allele. These findings exclude a strong effect of this ADRA2C marker on risk for ADHD in our sample of adult proband families. © 2004 Wiley‐Liss, Inc.