Association between the brain‐derived neurotrophic factor 196G/A polymorphism and eating disorders | Zendy

Koizumi Hiroki | Zendy; Hashimoto Kenji | Zendy; Itoh Kanako | Zendy; Nakazato Michiko | Zendy; Shimizu Eiji | Zendy; Ohgake Shintaro | Zendy; Koike Kaori | Zendy; Okamura Naoe | Zendy; Matsushita Sachio | Zendy; Suzuki Kenji | Zendy; Murayama Masanobu | Zendy; Higuchi Susumu | Zendy; Iyo Masaomi | Zendy

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Association between the brain‐derived neurotrophic factor 196G/A polymorphism and eating disorders

Author(s) -

Koizumi Hiroki,

Hashimoto Kenji,

Itoh Kanako,

Nakazato Michiko,

Shimizu Eiji,

Ohgake Shintaro,

Koike Kaori,

Okamura Naoe,

Matsushita Sachio,

Suzuki Kenji,

Murayama Masanobu,

Higuchi Susumu,

Iyo Masaomi

Publication year - 2003

Publication title -

american journal of medical genetics part b: neuropsychiatric genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.393

H-Index - 126

eISSN - 1552-485X

pISSN - 1552-4841

DOI - 10.1002/ajmg.b.20153

Subject(s) - eating disorders , genotype , brain derived neurotrophic factor , neurotrophic factors , bulimia nervosa , medicine , polymorphism (computer science) , pathophysiology , pathogenesis , endocrinology , genotype frequency , psychology , gene , psychiatry , genetics , biology , receptor

Several lines of evidence suggest that genetic factors might contribute to the pathogenesis of eating disorders and that brain‐derived neurotrophic factor (BDNF) plays a role in the pathophysiology of eating disorders. To investigate the role of the BDNF gene in the susceptibility to eating disorders, we analyzed the BDNF 196G/A gene polymorphism in female patients with eating disorders and female normal controls. The difference in the genotype frequency between patients (n = 198) and normal controls (n = 222) was statistically significant ( P = 0.029). Interestingly, a significant ( P = 0.015) difference in the genotype frequency between normal controls and bulimia nervosa patients (n = 101) with binge‐purging type was detected. This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders.© 2003 Wiley‐Liss, Inc.

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