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Association between the brain‐derived neurotrophic factor 196G/A polymorphism and eating disorders
Author(s) -
Koizumi Hiroki,
Hashimoto Kenji,
Itoh Kanako,
Nakazato Michiko,
Shimizu Eiji,
Ohgake Shintaro,
Koike Kaori,
Okamura Naoe,
Matsushita Sachio,
Suzuki Kenji,
Murayama Masanobu,
Higuchi Susumu,
Iyo Masaomi
Publication year - 2003
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.20153
Subject(s) - eating disorders , genotype , brain derived neurotrophic factor , neurotrophic factors , bulimia nervosa , medicine , polymorphism (computer science) , pathophysiology , pathogenesis , endocrinology , genotype frequency , psychology , gene , psychiatry , genetics , biology , receptor
Several lines of evidence suggest that genetic factors might contribute to the pathogenesis of eating disorders and that brain‐derived neurotrophic factor (BDNF) plays a role in the pathophysiology of eating disorders. To investigate the role of the BDNF gene in the susceptibility to eating disorders, we analyzed the BDNF 196G/A gene polymorphism in female patients with eating disorders and female normal controls. The difference in the genotype frequency between patients (n = 198) and normal controls (n = 222) was statistically significant ( P = 0.029). Interestingly, a significant ( P = 0.015) difference in the genotype frequency between normal controls and bulimia nervosa patients (n = 101) with binge‐purging type was detected. This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders.© 2003 Wiley‐Liss, Inc.