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Genetic mapping using haplotype and model‐free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31‐33
Author(s) -
Hong Kyung Sue,
McInnes L. Alison,
Service Susan K.,
Song Terry,
Lucas Jennifer,
Silva Sandra,
Fournier Eduardo,
León Pedro,
Molina Julio,
Reus Victor I.,
Sandkuijl Lodewijk A.,
Freimer Nelson B.
Publication year - 2003
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.20091
Subject(s) - locus (genetics) , haplotype , genetics , microsatellite , allele , identity by descent , biology , genetic linkage , linkage disequilibrium , gene
We report further evidence for our previous suggestion [Garner et al., 2001: Am J Hum Genet 68:1061–1064] of a locus on 5q predisposing to bipolar I disorder (BP‐I) in an extended Costa Rican pedigree. We genotyped additional microsatellite markers in this region and applied a multi‐point non‐parametric linkage analysis (SimWalk2). Significant identity‐by‐descent allele sharing among affected relatives was observed for all of the 20 markers tested in a segment of approximately 15 cM. Most affected individuals shared a single haplotype over this region; breaks within this haplotype may suggest a more restricted candidate location for a BP‐I gene. These results support the suggestion that a locus at 5q31‐33, together with a previously reported locus at 18q22‐23, may provide the major genetic risk for BP‐I in this family. © 2003 Wiley‐Liss, Inc.