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Association between interleukin 1‐β promoter (−511) polymorphism and depressive symptoms in Alzheimer's disease
Author(s) -
McCulley Michelle C.,
Day Ian N.M.,
Holmes Clive
Publication year - 2003
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.20086
Subject(s) - genotype , allele , polymorphism (computer science) , heterozygote advantage , alzheimer's disease , dementia , disease , medicine , genetics , depression (economics) , depressive symptoms , biology , psychiatry , gene , anxiety , macroeconomics , economics
Depressive symptoms have been associated with raised interleukin 1‐β (IL‐1β) plasma levels. The presence of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease, including depressive symptoms, have been shown to be influenced by common genetic polymorphisms. A common polymorphism in the promoter region of IL‐1β has been linked to altered synthesis of IL‐1β. We hypothesize that this common genetic polymorphism is a risk factor for the appearance of depressive symptoms in AD. A total of 133 subjects, diagnosed as probable AD and 156 controls were genotyped for the −511 variant of IL‐1β. Neither genotype or allele frequencies differed between the AD and control group. However, an allelic association was found between the T variant and the symptoms of depression in AD subjects. Genotypic analysis showed that heterozygotes were three times more likely to develop depressive symptoms than CC homozygotes. © 2003 Wiley‐Liss, Inc.