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A psychometrically derived impulsive trait related to a polymorphism in the serotonin transporter gene‐linked polymorphic region (5‐HTTLPR) in a japanese nonclinical population: Assessment by the barratt impulsiveness scale (BIS)
Author(s) -
Sakado Kaoru,
Sakado Miwako,
Muratake Tatsuyuki,
Mundt Christoph,
Someya Toshiyuki
Publication year - 2003
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.20063
Subject(s) - barratt impulsiveness scale , serotonin transporter , 5 httlpr , genotype , allele , genetics , polymorphism (computer science) , allele frequency , trait , psychology , biology , impulsivity , gene , clinical psychology , computer science , programming language
Although a number of studies have shown that human impulsive traits are associated with indices of central serotonin function, few researchers have investigated the relationship between a polymorphism in the serotonin transporter gene‐linked region (5‐HTTLPR) and a psychometrically derived impulsive trait. We determined the 5‐HTTLPR polymorphism in 123 employed Japanese male adults using the polymerase chain reaction. The distribution of allelic frequency was determined and also investigated the relationship of the 5‐HTTLPR polymorphism to a impulsive trait as measured by the Barratt Impulsiveness Scale, 11th version (BIS‐11). The distribution of allelic frequency was found to be almost identical to that previously reported in Japanese (the frequency for the long (L)/L, L/short (S), and S/S genotypes was: 3, 28, and 68%, respectively). In a comparison between the genotype groups, the S/S genotype group significantly higher scored for the total BIS‐11 and the subscale attentional impulsiveness than the L/S + L/L genotype group. These findings suggest that individuals with a homozygous S‐allele may be more impulsive than those with the other genotype. © 2003 Wiley‐Liss, Inc.