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Genetic dissection of psychopathological symptoms: Insomnia in mood disorders and CLOCK gene polymorphism
Author(s) -
Serretti Alessandro,
Benedetti Francesco,
Mandelli Laura,
Lorenzi Cristina,
Pirovano Adele,
Colombo Cristina,
Smeraldi Enrico
Publication year - 2003
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.20053
Subject(s) - insomnia , clock , psychopathology , polymorphism (computer science) , mood disorders , major depressive disorder , bipolar disorder , mood , medicine , psychology , genetics , psychiatry , gene , biology , circadian rhythm , genotype , circadian clock , anxiety
We investigated the possible effect of the 3111T/C CLOCK gene polymorphism on sleep disorders in a sample of 620 patients affected by major depressive disorder (MDD) and bipolar disorder (BP). We detected a significantly higher recurrence of initial ( P = 0.0001), middle ( P = 0.0009), and early ( P = 0.0008) insomnia in homozygotes for the C variant and a similar trend concerning decreased need of sleep in BP ( P = 0.0074). Other demographic and clinical features were found not related with CLOCK polymorphisms. This preliminary observation leads to hypothesize a possible involvement of the CLOCK gene polymorphism in the sleep disregulations in MDD and BP. Copyright © 2003 Wiley‐Liss, Inc.