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Genome wide scan using homozygosity mapping and linkage analyses of a single pedigree with affective disorder suggests oligogenic inheritance
Author(s) -
Ewald Henrik,
Kruse Torben A.,
Mors Ole
Publication year - 2003
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.20039
Subject(s) - genetics , genetic linkage , biology , linkage (software) , locus (genetics) , haplotype , bipolar disorder , allele , gene , cognition , neuroscience
The present study reports results from a genome scan on a family with bipolar affective disorder in which the parents are first cousins and four of the offsprings and one grandchild have affective disorder. The study searched for risk loci for affective disorder by searching for homozygous segments or more complex inherited loci using parametric and non‐parametric multipoint linkage analysis. In addition dominant, multipoint, affecteds‐only linkage analyses were performed as a supplement to previous analyses. On chromosomes 2q31.3, 10, 12q24, and 21q22.3 evidence for a risk locus was obtained by parametric and/or non‐parametric linkage analyses and by haplotype sharing. As other studies have found significant or suggestive linkage to bipolar disorder in these chromosome regions this suggests that an oligogenic mode of inheritance is possible in this family involving at least some of the loci. Finally, the work discusses whether homozygosity mapping using parametric and non‐parametric linkage analyses may be of value for complex diseases including rare subphenotypes of such disorders. © 2003 Wiley‐Liss, Inc.