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Dopamine D2 receptor gene Ser311Cys variant and schizophrenia: association study and meta‐analysis
Author(s) -
Jönsson Erik G,
Sillén Anna,
Vares Maria,
Ekholm Birgit,
Terenius Lars,
Sedvall Göran C
Publication year - 2003
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.20004
Subject(s) - meta analysis , schizophrenia (object oriented programming) , dopamine receptor d2 , association (psychology) , dopamine receptor , dopamine receptor d3 , gene , dopamine , genetics , genetic association , receptor , biology , medicine , neuroscience , psychology , psychiatry , single nucleotide polymorphism , genotype , psychotherapist
An association has been reported between a dopamine D 2 receptor gene ( DRD2 ) Ser311Cys variant and schizophrenia. In a replication attempt, Swedish patients with schizophrenia (n = 173) and control subjects (n = 236) were assessed for the DRD2 Ser311Cys variant. Schizophrenic patients displayed higher Cys311 allele frequencies than control subjects (4.0 vs. 0.8%, χ 2 = 9.49, df = 1, P = 0.002; odds ratio (OR) 4.93, 95% confidence interval (95% CI) 1.61–15.12). The association was detected only in men. The results were supported by a meta‐analysis of all published case–control studies comprising a total of 9,152 subjects (χ 2 = 11.37, df = 1, P < 0.001; OR 1.43, 95% CI 1.16–1.78). The present results support the involvement of the DRD2 gene in the pathogenesis of schizophrenia. © 2003 Wiley‐Liss, Inc.
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