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Early‐onset schizophrenia and dopamine‐related gene polymorphism
Author(s) -
Iwata Yasuhide,
Matsumoto Hideo,
Minabe Yoshio,
Osada Naoko,
Nakamura Kazuhiko,
Sekizawa Takahiro,
Suzuki Katsuaki,
Sekine Yoshimoto,
Takei Nori,
Mori Norio
Publication year - 2002
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.10759
Subject(s) - catechol o methyl transferase , dopamine , allele , polymorphism (computer science) , genotyping , genotype , dopamine receptor , genetics , monoamine oxidase a , gene , biology , medicine , endocrinology , receptor , serotonin
Schizophrenic patients with an onset before age 16 years (early‐onset schizophrenia, EOS) would be a rare but attractive subpopulation for genetic studies. This study explored the relationship between the polymorphism of four dopamine‐regulating‐enzymes (tyrosine hydroxylase, dopamine‐β‐hydroxylase, catechol‐ O ‐methltransferase, monoamine oxidase‐A) genes, four dopamine‐receptors (dopamine D1, D2, D3, D4 receptors) genes and susceptibility to EOS in a Japanese sample. Subjects comprised 51 Japanese patients who met DSM‐IV criteria for schizophrenia with an onset before age 16 (by age 15) and 148 Japanese healthy controls. DNA was extracted from whole blood and genotyping was carried out by PCR‐RELP using each restriction endonuclease. No significant difference was found in the allele frequencies or genotype distributions of any of the eight genes examined between EOS and the control groups. We did not find the relationship between the polymorphism of eight dopamine‐related genes and susceptibility to EOS in a Japanese sample. © 2002 Wiley‐Liss, Inc.