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Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia
Author(s) -
IwayamaShigeno Yoshimi,
Yamada Kazuo,
Toyota Tomoko,
Shimizu Hiromitsu,
Hattori Eiji,
Yoshitsugu Kiyoshi,
Fujisawa Tetsuya,
Yoshida Yukako,
Kobayashi Toshio,
Toru Michio,
Kurumaji Akeo,
DeteraWadleigh Sevilla,
Yoshikawa Takeo
Publication year - 2002
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.10053
Subject(s) - haplotype , genetics , schizophrenia (object oriented programming) , linkage disequilibrium , allele , biology , gene , dopaminergic , genetic association , dopamine , genotype , medicine , neuroscience , single nucleotide polymorphism , psychiatry
Dysregulation in dopaminergic neurotransmission might play a role in the pathogenesis of schizophrenia, and therefore genetic components of the dopamine (DA) pathway may confer risk. The NR4A2 (Nurr1) gene is essential for the development and maintenance of mesencephalic DA‐synthesizing neurons. Moreover, Nurr1 forms a heterodimer with the retinoid X receptor and disturbances in the retinoid‐signaling cascade may be involved in susceptibility to schizophrenia. To investigate the potential genetic contribution of NR4A2 , we performed a case‐control association study using three common variants in the gene [−2922(C)2‐3, IVS6 + 17∼+18insG, EX8 + 657(CA)9‐10] that were in strong linkage disequilibrium with each other. We did not detect a significant allelic or genotypic association. Haplotypes derived from all three polymorphisms generated similar results. These data do not support the notion that the NR4A2 gene plays a major role in risk for schizophrenia among Japanese individuals. © 2003 Wiley‐Liss, Inc.