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Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population
Author(s) -
Lee HeonJeong,
Lee HongSeock,
Kim YongKu,
Kim SeungHyun,
Kim Leen,
Lee Min Soo,
Joe SookHaeng,
Jung InKwa,
Suh KwangYoon,
Kim Sangduk
Publication year - 2002
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.10047
Subject(s) - novelty seeking , genetics , allele , polymorphism (computer science) , big five personality traits , biology , personality , snp , population , reward dependence , exon , gene , single nucleotide polymorphism , psychology , genotype , medicine , social psychology , environmental health
Polymorphism in exon III of the dopamine D4 receptor (DRD4) gene has been implicated to be associated with the human personality trait of novelty seeking (NS). For this study, we have investigated the possible association between 48‐bp VNTR in exon III and −521 C/T SNP of the DRD4 and personality traits among young (≈14 years of age) Korean female population. We found that the interaction between the two alleles of DRD4 polymorphism, 48‐bp VNTR and −521 C/T, were significantly high on NS ( F = 4.88, P = 0.029) and persistence (P) ( F = 5.05, P = 0.027) personality scores, suggesting that the variants of DRD4 gene influence the NS and P (persistent) personality traits. When analyzed independently, however, the two different alleles of DRD4 polymorphisms, 48‐bp VNTR and −521 C/T, there was no direct correlation with the personality traits. © 2002 Wiley‐Liss, Inc.