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Association study between dopamine D 3 receptor gene variant and personality traits
Author(s) -
Jönsson Erik G.,
Burgert Edgar,
Crocq MarcAntoine,
Gustavsson J Petter,
Forslund Kaj,
MattilaEvenden Marja,
Rylander Gunnar,
Flyckt Lena K.,
Bjerkenstedt Lars,
Wiesel FritsAxel,
Åsberg Marie,
Bergman Hans
Publication year - 2002
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.10009
Subject(s) - novelty seeking , cooperativeness , temperament and character inventory , psychology , big five personality traits , alternative five model of personality , personality , reward dependence , population , clinical psychology , developmental psychology , temperament , big five personality traits and culture , social psychology , demography , sociology
Dopamine receptor gene variation has been hypothesized to influence personality traits characterized by novelty seeking and related traits. We analyzed a dopamine D 3 receptor gene (DRD3) variant in a Swedish population ( n = 373) investigated with one or more of several personality questionnaires. No significant relationships were found between DRD3 genotypes and any of the 15 Karolinska Scales of Personality (KSP) and five Health‐relevant Personality 5 factor inventory (HP5i) scales. The DRD3 variant was associated with some scales related to novelty seeking: the Swedish universities Scales of Personality (SSP) Adventure Seeking and the revised NEO personality inventory (NEO‐PI‐R) Fantasy (O1) and Order (C2) scales. There were also associations with the Temperament and Character Inventory (TCI) Cooperativeness and Compassion (C4) scales. After correction for multiple testing, however, no significant difference remained. We conclude that the investigated DRD3 polymorphism does not have a major impact on personality in the investigated population. © 2003 Wiley‐Liss, Inc.