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An investigation of the 5‐HT 2C receptor gene as a migraine candidate gene
Author(s) -
Johnson Matthew P.,
Lea Rod A.,
Curtain Robert P.,
MacMillan John C.,
Griffiths Lyn R.
Publication year - 2002
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.10007
Subject(s) - migraine , genetics , migraine with aura , candidate gene , gene , pedigree chart , genetic linkage , locus (genetics) , single nucleotide polymorphism , biology , aura , familial hemiplegic migraine , coding region , medicine , genotype , psychiatry
Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X‐linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24–q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C ( 5‐HT 2C ) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5‐HT 2C gene. In addition, exonic coding regions of the 5‐HT 2C gene were also sequenced for mutations in X‐linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5‐HT 2C gene in migraine predisposition. © 2003 Wiley‐Liss, Inc.