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Dysmorphism and major anomalies are a main predictor of survival in newborns admitted to the neonatal intensive care unit in the Democratic Republic of Congo
Author(s) -
Mubungu Gerrye,
Makay Prince,
Lumaka Aimé,
Mvuama o,
Tshika Dahlie,
Tady BrunoPaul,
Biselele Thérèse,
Roelants Mathieu,
Tshilobo Prosper Lukusa,
Devriendt Koenraad
Publication year - 2021
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.61987
Subject(s) - neonatal intensive care unit , medicine , asphyxia , pediatrics , intensive care unit , neonatal death , intensive care , hazard ratio , intensive care medicine , fetus , pregnancy , confidence interval , biology , genetics
In Central‐Africa, neonatal infections, asphyxia and prematurity are main reasons for admission to the neonatal intensive care unit and major determinants of newborn survival. Also, the outcome of newborns with congenital anomalies is expected to be poor, due to a lack of state‐of‐the art care. We conducted a study of 102 newborns recruited in the Neonatal Intensive Care Unit (NICU) at the University Hospitals of Kinshasa, DR Congo, to assess the impact of congenital anomalies. The presence of a major anomaly was associated with a hazard ratio of death of 13.2 (95%CI: 3.7–46.7, p < .001). In addition, the presence of three or more minor anomalies was associated with a 4.5‐fold increased risk of death (95%CI: 1.1–18.6, p = .04). We conclude that like major anomalies, the presence of three or more minor anomalies should also be given particular attention and that the evaluation of dysmorphism should be promoted in NICU.