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Clinical manifestations of osteogenesis imperfecta in adulthood: An integrative review of quantitative studies and case reports
Author(s) -
Chougui Khadidja,
Addab Sofia,
Palomo Telma,
Morin Suzanne N.,
Veilleux LouisNicolas,
Bernstein Mitchell,
Thorstad Kelly,
Hamdy Reggie,
Tsimicalis Argerie
Publication year - 2020
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.61497
Subject(s) - osteogenesis imperfecta , generalizability theory , medicine , checklist , medline , amelogenesis imperfecta , pediatrics , pathology , psychology , developmental psychology , dentistry , enamel paint , political science , law , cognitive psychology
Osteogenesis imperfecta (OI) is a rare genetic disorder of the bones caused by a mutation in Type I collagen genes. As adults with OI are aging, medical concerns secondary to OI may arise. This integrative review sought to review, appraise, and synthesize the clinical manifestations faced by adults with OI. Four electronic bibliographic databases were searched. Published quantitative, qualitative, and mixed‐methods studies, as well as case reports from 2000 to March 2019, addressing a clinical manifestation in adulthood, were reviewed. Eligible studies and case reports were subsequently appraised using the Mixed Methods Appraisal Tool and Case Report Checklist, respectively. Twenty quantitative studies and 88 case reports were included for review regardless of the varying methodological quality score. These studies collectively included 2,510 adults with different OI types. Several clinical manifestations were studied, and included: hearing loss, cardiac diseases, pregnancy complications, cerebrovascular manifestations, musculoskeletal manifestations, respiratory manifestations, vision impairment, and other clinical manifestations. Increased awareness may optimize prevention, treatment, and follow‐up. Opportunities to enhance the methodological quality of research including better design and methodology, multisite collaborations, and larger and diverse sampling will optimize the generalizability and transferability of findings.