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Anti‐Müllerian hormone levels in patients with turner syndrome: Relation to karyotype, spontaneous puberty, and replacement therapy
Author(s) -
Hamza Rasha T.,
Mira Marwa F.,
Hamed Amira I.,
Ezzat Treiz,
Sallam Mahmoud T.
Publication year - 2018
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.40473
Subject(s) - anti müllerian hormone , medicine , endocrinology , luteinizing hormone , ovarian reserve , turner syndrome , premature ovarian failure , breast development , infertility , follicle stimulating hormone , delayed puberty , folliculogenesis , hormone , biology , pregnancy , genetics , lactation
Most girls with Turner syndrome (TS) suffer from incomplete sexual development, premature ovarian failure, and infertility due to abnormal ovarian folliculogenesis. Serum anti‐Müllerian hormone (AMH) levels reflect the ovarian reserve in females, even in childhood. Thus, we aimed to assess serum AMH levels in girls with TS and its relation to karyotype, spontaneous puberty, and growth hormone (GH) therapy. Fifty TS were compared to 50 age‐ and sex‐matched controls. All subjects were subjected to history, anthropometric assessment, Tanner pubertal staging and measurement of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and AMH. Karyotype results were obtained from patients’ records. Serum AMH was measurable in 12 TS patients (24%). The lowest frequency of measurable AMH was in patients with a karyotype of 45,X. The measurable AMH was associated with spontaneous breast development ( p = .003) and spontaneous menarche ( p = .001). AMH correlated negatively with FSH ( r = −.846, p = .000) and LH ( r = −.83, p = .034). GH therapy increased the odds of having measurable AMH in TS girls ( p = .002). In conclusion, AMH was associated with karyotype, spontaneous pubertal development, LH, and FSH in TS girls and may serve as a useful marker of ovarian function and ongoing follicular development in prepuberty.