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Pharmacological interventions to improve cognition and adaptive functioning in Down syndrome: Strides to date
Author(s) -
Hart Sarah J.,
Visootsak Jeannie,
Tamburri Paul,
Phuong Patrick,
Baumer Nicole,
Hernandez MariaClemencia,
Skotko Brian G.,
OchoaLubinoff Cesar,
Liogier D'Ardhuy Xavier,
Kishnani Priya S.,
Spiridigliozzi Gail A.
Publication year - 2017
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.38465
Subject(s) - psychological intervention , cognition , clinical trial , pharmaceutical industry , medicine , psychology , clinical psychology , psychiatry , pharmacology , pathology
Although an increasing number of clinical trials have been developed for cognition in Down syndrome, there has been limited success to date in identifying effective interventions. This review describes the progression from pre‐clinical studies with mouse models to human clinical trials research using pharmacological interventions to improve cognition and adaptive functioning in Down syndrome. We also provide considerations for investigators when conducting human clinical trials and describe strategies for the pharmaceutical industry to advance the field in drug discovery for Down syndrome. Future research focusing on earlier pharmaceutical interventions, development of appropriate outcome measures, and greater collaboration between industry, academia, advocacy, and regulatory groups will be important for addressing limitations from prior studies and developing potential effective interventions for cognition in Down syndrome.