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Progressive macrothrombocytopenia and hearing loss in a large family with DIAPH1 related disease
Author(s) -
Ganaha Akira,
Kaname Tadashi,
Shinjou Ayano,
Chinen Yasutsugu,
Yanagi Kumiko,
Higa Teruyuki,
Kondo Shunsuke,
Suzuki Mikio
Publication year - 2017
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.38411
Subject(s) - hearing loss , sensorineural hearing loss , medicine , sanger sequencing , audiology , genetics , biology , gene , mutation
In this study, we describe a Japanese family with progressive hearing loss and macrothrombocytopenia. Using next‐generation and Sanger sequencing analyses, we identified a heterozygous variant in exon 27 of the DIAPH1 gene (NM_005219), c.3637C>T, p.R1213X. All patients in the family had sensorineural hearing loss and macrothrombocytopenia. None of the patients exhibited a tendency to bleed. No pathogenic variants were found in the MYH9 gene. Hearing loss began with high‐frequency loss during early childhood and progressed to severe hearing loss involving all frequencies. Analyses of the mean platelet volume and platelet distribution width indicated that the macrothrombocytopenia is progressive in patients with DIAPH1 related disease.There are no reports describing progressive macrothrombocytopenia in patients with pathogenic variants of DIAPH1 . Thus, progressive macrothrombocytopenia may be a novel feature of deafness patients with pathogenic variants in DIAPH1 .