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Nomenclature and definition in asymmetric regional body overgrowth
Author(s) -
Kalish Jennifer M.,
Biesecker Leslie G.,
Brioude Frederic,
Deardorff Matthew A.,
Di CesareMerlone Alessandra,
Druley Todd,
Ferrero Giovanni B.,
Lapunzina Pablo,
Larizza Lidia,
Maas Saskia,
Macchiaiolo Marina,
Maher Eamonn R.,
Maitz Silvia,
MartinezAgosto Julian A.,
Mussa Alessandro,
Robinson Peter,
Russo Silvia,
Selicorni Angelo,
Hennekam Raoul C.
Publication year - 2017
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.38266
Subject(s) - hemihypertrophy , nomenclature , etiology , dysplasia , heterotaxy , anatomy , congenital malformations , cortical dysplasia , biology , genetics , evolutionary biology , pathology , medicine , neuroscience , zoology , epilepsy , taxonomy (biology) , pregnancy , heart disease
We designate a novel term “isolated lateralized overgrowth” (ILO) for the findings previously described as “isolated hemihypertrophy” and “isolated hemihyperplasia.” ILO is defined as lateralized overgrowth in the absence of a recognized pattern of malformations, dysplasia, or morphologic variants. ILO is likely genetically heterogeneous. Further study is required to determine more of the underlying genetic etiologies and potential associations with currently unrecognized patterns of malformation.