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Childhood cancer predisposition syndromes—A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology
Author(s) -
Ripperger Tim,
Bielack Stefan S.,
Borkhardt Arndt,
Brecht Ines B.,
Burkhardt Birgit,
Calaminus Gabriele,
Debatin KlausMichael,
Deubzer Hedwig,
Dirksen Uta,
Eckert Cornelia,
Eggert Angelika,
Erlacher Miriam,
Fleischhack Gudrun,
Frühwald Michael C.,
Gnekow Astrid,
Goehring Gudrun,
Graf Norbert,
Hanenberg Helmut,
Hauer Julia,
Hero Barbara,
Hettmer Simone,
von Hoff Katja,
Horstmann Martin,
Hoyer Juliane,
Illig Thomas,
Kaatsch Peter,
Kappler Roland,
Kerl Kornelius,
Klingebiel Thomas,
Kontny Udo,
Kordes Uwe,
Körholz Dieter,
Koscielniak Ewa,
Kramm Christof M.,
Kuhlen Michaela,
Kulozik Andreas E.,
Lamottke Britta,
Leuschner Ivo,
Lohmann Dietmar R.,
Meinhardt Andrea,
Metzler Markus,
Meyer Lüder H.,
Moser Olga,
Nathrath Michaela,
Niemeyer Charlotte M.,
Nustede Rainer,
Pajtler Kristian W.,
Paret Claudia,
Rasche Mareike,
Reinhardt Dirk,
Rieß Olaf,
Russo Alexandra,
Rutkowski Stefan,
Schlegelberger Brigitte,
Schneider Dominik,
Schneppenheim Reinhard,
Schrappe Martin,
Schroeder Christopher,
von Schweinitz Dietrich,
Simon Thorsten,
SparberSauer Monika,
Spix Claudia,
Stanulla Martin,
Steinemann Doris,
Strahm Brigitte,
Temming Petra,
Thomay Kathrin,
von Bueren Andre O.,
Vorwerk Peter,
Witt Olaf,
Wlodarski Marcin,
Wössmann Willy,
Zenker Martin,
Zimmermann Stefanie,
Pfister Stefan M.,
Kratz Christian P.
Publication year - 2017
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.38142
Subject(s) - genetic predisposition , cancer , medicine , hematology , oncology , disease
Heritable predisposition is an important cause of cancer in children and adolescents. Although a large number of cancer predisposition genes and their associated syndromes and malignancies have already been described, it appears likely that there are more pediatric cancer patients in whom heritable cancer predisposition syndromes have yet to be recognized. In a consensus meeting in the beginning of 2016, we convened experts in Human Genetics and Pediatric Hematology/Oncology to review the available data, to categorize the large amount of information, and to develop recommendations regarding when a cancer predisposition syndrome should be suspected in a young oncology patient. This review summarizes the current knowledge of cancer predisposition syndromes in pediatric oncology and provides essential information on clinical situations in which a childhood cancer predisposition syndrome should be suspected.