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Quality of life in adolescents and adults with CHARGE syndrome
Author(s) -
Hartshorne Nancy,
Hudson Alexandra,
MacCuspie Jillian,
Kennert Benjamin,
Nacarato Tasha,
Hartshorne Timothy,
Blake Kim
Publication year - 2016
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.37769
Subject(s) - anxiety , quality of life (healthcare) , intervention (counseling) , psychology , clinical psychology , fear of falling , aggression , medicine , psychiatry , gerontology , poison control , injury prevention , environmental health , psychotherapist
Health‐related Quality of Life and the Impact of Childhood Neurologic Disability Scale were collected for 53 patients with CHARGE syndrome aged 13–39 years with a mean academic level of 4th grade. The most prevalent new and ongoing issues included bone health issues, sleep apnea, retinal detachment, anxiety, and aggression. Sleep issues were significantly correlated with anxiety, self‐abuse, conduct problems, and autistic‐like behaviors. Problems with overall health, behavior, and balance most affected the number of social activities in the individual's life. Sensory impairment most affected relationships with friends. Two contrasting case studies are presented and demonstrate that the quality of life exists on a broad spectrum in CHARGE syndrome, just as its physical features range from mild to very severe. A multitude of factors, including those beyond the physical manifestations, such as anxiety and sleep problems, influence quality of life and are important areas for intervention. © 2016 Wiley Periodicals, Inc.