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Tatton–Brown–Rahman syndrome due to 2p23 microdeletion
Author(s) -
Okamoto Nobuhiko,
Toribe Yasuhisa,
Shimojima Keiko,
Yamamoto Toshiyuki
Publication year - 2016
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.37588
Subject(s) - cytosine , genetics , mutation , intellectual disability , biology , medicine , gene
Tatton–Brown–Rahman syndrome is a new overgrowth syndrome due to DNMT3A (DNA cytosine 5 methyltransferase 3A) mutations. Mutation carriers show a distinctive facial appearance, intellectual disability, and increased height. We report a patient with overgrowth who showed submicroscopic deletion of chromosome 2p23 including DNMT3A . The deletion was detected by array‐CGH. He showed moderate ID and distinctive facial gestalt. His clinical features were consistent with those of Tatton–Brown–Rahman syndrome. We suggest that 2p23 microdeletion including DNMT3A may cause similar symptoms in patients with DNMT3A mutations and should be considered in patients with overgrowth. © 2016 Wiley Periodicals, Inc.