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A case study of brain morphometry in triplets discordant for Down syndrome
Author(s) -
Adeyemi Elizabeth I.,
Giedd Jay N.,
Lee Nancy Raitano
Publication year - 2015
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.36820
Subject(s) - down syndrome , medicine , psychology , psychiatry
Down syndrome, the most common genetic cause of intellectual disability, offers the opportunity to explore the associations between genetics and both neuroanatomic and neuropsychological phenotypes. This case report summarizes the findings of a neuroimaging and neuropsychology study of two adolescent females with Down syndrome and their same‐sex discordant triplet siblings (one from each family; n = 4). Using high‐resolution magnetic resonance imaging and surface based morphometric approaches, we offer the first in vivo report of cortical surface area reductions and increases in the thickness of the cortical sheet in youth with Down syndrome relative to their typically developing same‐sex triplet siblings. © 2015 Wiley Periodicals, Inc.