Premium
Proposed regulations for research with biospecimens: Responses from stakeholders at CTSA consortium institutions
Author(s) -
Botkin Jeffrey R.,
Anderson Rebecca,
Murray Tom,
Beskow Laura M.,
Maschke Karen,
Cuttler Leona
Publication year - 2014
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.36365
Subject(s) - notice , rulemaking , translational research , government (linguistics) , public relations , human research , political science , business , medical education , medicine , public administration , engineering ethics , engineering , linguistics , philosophy , pathology , law
Secondary research with biospecimens acquired through clinical care and through research is often conducted without the informed consent of individuals from whom the specimens were acquired. While such uses are consistent with the current federal regulations, surveys of the general public suggest that many individuals would prefer more information and choice regarding research use of biospecimens. The federal government issued an Advance Notice of Proposed Rulemaking (ANPRM) in 2011 that proposed a number of potential changes in the regulations governing human subjects. These proposed regulations are particularly pertinent to institutions committed to research involving human subjects—including institutions in the NIH‐funded Clinical and Translational Science Awards (CTSA) consortium. In this study, we reviewed public responses by CTSA‐funded institutions and CTSA‐affiliated organizations and groups regarding the proposed changes in the ANPRM with respect to research with biospecimens. Our results indicate that the majority of responses to the ANPRM from CTSA institutions were not supportive of the proposed changes. While many responses acknowledge a need to change current research practices regarding biospecimens, the proposed changes in the ANPRM received only limited support from this subgroup of academic research institutions. © 2014 Wiley Periodicals, Inc.