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Perspectives on RAGE signaling and its role in cardiovascular disease
Author(s) -
Cohen M. Michael
Publication year - 2013
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.36181
Subject(s) - rage (emotion) , hmgb1 , disease , signal transduction , calcium binding protein , microbiology and biotechnology , receptor , chemistry , immunology , biology , medicine , neuroscience , calcium
RAGE stands for R eceptor of A dvanced Gl ycation E ndproducts. The two main topics discussed are (1) the nature of RAGE signaling and (2) its role in cardiovascular disease. RAGE may occur in membrane‐bound form or in secretory form. RAGE signaling involves multiple ligands: (1) several AGEs (2) amyloid β pecursor protein ( APP ), (3) high mobility group box 1 ( HMGB1 ), (4) S100A4 , (5) S100A8/A9 , and (6) S100A12 , which are calcium‐binding proteins, and (7) S100B , a glial‐derived protein. RAGE ligands and various diseases involving RAGE signaling are summarized in tabular form. © 2013 Wiley Periodicals, Inc.