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Two cases of hepatic adenomas in patients with wolf‐hirschhorn syndrome: A new rare complication?
Author(s) -
Prunotto Giulia,
Cianci Paola,
Cereda Anna,
Scatigno Agnese,
Fossati Chiara,
Maitz Silvia,
Biondi Andrea,
Selicorni Angelo
Publication year - 2013
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.35966
Subject(s) - complication , medicine , failure to thrive , pediatrics , psychomotor learning , facial dysmorphism , surgery , psychiatry , biochemistry , chemistry , cognition , gene , phenotype
Wolf–Hirschhorn syndrome (WHS) is a rare microdeletion syndrome associated with a characteristic facial appearance, failure to thrive, psychomotor delays, and various major malformations of internal organs; many medical complications have been described (feeding difficulties, epilepsy, hearing problems). Benign or malignant oncologic problems are not a typical feature of the natural history of these patients. We report on two patients with WHS patients in whom hepatic adenoma (HA) were diagnosed during adolescence. The clinical evolution of liver involvement was different between the two. We discuss the possibility of considering HA as a rare medical problem in the follow‐up of WHS patients. © 2013 Wiley Periodicals, Inc.