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Congenital isolated leukonychia totalis in three Egyptian sibs
Author(s) -
Afifi Hanan H.,
AbdelHamid Mahmoud F.,
Zaki Maha S.
Publication year - 2011
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.33907
Subject(s) - offspring , inheritance (genetic algorithm) , genetics , autosomal recessive inheritance , biology , sister , dermatology , medicine , gene , pregnancy , sociology , anthropology
Isolated leukonychia totalis is a rare condition of nails with mainly an autosomal dominant pattern of inheritance. In this report, we present three sibs (a sister and two brothers) with isolated congenital leukonychia totalis, without any manifestation among parents and other family members. The sibs had similar facial features and were offspring of consanguineous Egyptian parents. We discussed possible mechanisms of inheritance and suggested an autosomal recessive mode of transmission. © 2011 Wiley‐Liss, Inc.