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A study of 534 fetal pathology cases from prenatal diagnosis referrals analyzed from 1989 through 2000
Author(s) -
Laury Anna,
SanchezLara Pedro A.,
Pepkowitz Samuel,
Graham John M.
Publication year - 2007
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.32094
Subject(s) - geneticist , chromosomal abnormality , abnormality , genetic counseling , fetus , medicine , prenatal diagnosis , pediatrics , obstetrics , pregnancy , psychiatry , karyotype , biology , genetics , chromosome , gene
Useful and meaningful counseling following the discovery of a fetal loss or fetal anomalies requires an accurate diagnosis. In order to achieve this, our center utilized a multidisciplinary approach which included an ultrasonographer, perinatologist, genetic counselor, dysmorphologist, clinical geneticist, and pathologist. In this article, we report our experience with the analysis and evaluation of 534 cases seen between 1989 and 2000. In total, we were able to identify the cause of fetal loss in 369 cases (69%). In 98/369 cases (18.4%) the condition was attributed to a Mendelian process and in 78 (14.6%), to chromosomal abnormalities. The overall average maternal age was 31.6 years, the maternal age in cases of chromosomal abnormality was slightly higher (33.3 years). Our findings described below reiterate the clinical usefulness of a team specifically trained in the approach to fetal loss and/or fetal anomalies. © 2007 Wiley‐Liss, Inc.