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Dominantly‐inherited lop ears
Author(s) -
Leung Alexander K.C.,
Kong Albert Y.F.,
Robson W. Lane M.,
McLeod D. Ross
Publication year - 2007
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.31933
Subject(s) - proband , inheritance (genetic algorithm) , anomaly (physics) , presentation (obstetrics) , genetics , biology , mode (computer interface) , medicine , gene , mutation , computer science , physics , condensed matter physics , radiology , operating system
We describe a four‐generation Chinese family that included five members who had an isolated bilateral lop ear anomaly. The presentation suggested a dominant mode of inheritance. The absence of male‐to‐male transmission does not exclude an X‐linked dominant mode of inheritance. Since the phenotypic anomaly of the male proband was no more severe than the affected female members, an autosomal dominant mode of inheritance is most likely. © 2007 Wiley‐Liss, Inc.