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The origin of trisomy 22: Evidence for acrocentric chromosome‐specific patterns of nondisjunction
Author(s) -
Hall Heather E.,
Surti Urvashi,
Hoffner Lori,
Shirley Sofia,
Feingold Eleanor,
Hassold Terry
Publication year - 2007
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.31918
Subject(s) - nondisjunction , trisomy , biology , genetics , centromere , chromosome , aneuploidy , meiosis , chromosome 21 , chromosome segregation , gene
Trisomy 22 is one of the most common trisomies in clinically recognized pregnancies, yet relatively little is known about the origin of nondisjunction for chromosome 22. Accordingly, we initiated studies to investigate the origin of the extra chromosome in 130 trisomy 22 cases. Our results indicate that the majority of trisomy 22 errors (>96%) arise during oogenesis with most of these errors (∼90%) occurring during the first meiotic division. As with other trisomies, failure to recombine contributed to nondisjunction of chromosome 22. Taken together with data available for other trisomies, our results suggest patterns of nondisjunction that are shared among the acrocentric, but not all nonacrocentric, chromosomes. © 2007 Wiley‐Liss, Inc.