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Non‐Latin European descent could be a requirement for association of NTDs and MTHFR variant 677C > T: A meta‐analysis
Author(s) -
Amorim Márcia R.,
Lima Marcelo A.C.,
Castilla Eduardo E.,
Orioli Iêda M.
Publication year - 2007
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.31812
Subject(s) - methylenetetrahydrofolate reductase , meta analysis , odds ratio , medicine , confidence interval , latin americans , genotype , genetics , allele , demography , biology , gene , political science , sociology , law
There are several studies that have found a positive association between neural tube defects (NTDs) and the common mutation 677C > T of 5,10‐methylenetetrahydrofolate reductase ( MTHFR ), and others that have not found such an association. We updated the meta‐analyses of the published data about NTDs and MTHFR 677C > T variant from January 1994 to October 2005 identifying 170 potentially relevant studies. After applying pertinent exclusion criteria, 37 different populations from 32 studies were included in the meta‐analysis, with a total of 3,530 cases and 6,296 controls. Further we stratified the data according to geographical region and ethnicity, and produced two separated meta‐analyses for non‐Latin European and Latin European descent populations. The general (odds ratio 1.41; 95% confidence interval 1.24–1.59), and the non‐Latin European meta‐analyses (1.62; 1.38–1.90) indicate an association of TT genotype and NTDs; no association was demonstrated for Latin European populations (1.16; 0.95–1.43). The examination of non‐Latin European studies revealed that the association of TT genotype with NTD has only been proven for Irish populations, both by case‐control studies, and by family‐based tests, such as the allele transmission disequilibrium test (TDT). © 2007 Wiley‐Liss, Inc.