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The genetic basis of tooth development and dental defects
Author(s) -
Thesleff Irma
Publication year - 2006
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.31360
Subject(s) - biology , gene , transcription factor , microbiology and biotechnology , signal transduction , genetics , transcription (linguistics) , linguistics , philosophy
More than 300 genes have so far been associated with tooth development, mainly in mouse embryos. The majority of them are associated with conserved signaling pathways mediating cellular communication, in particular between epithelial and mesenchymal tissues. Necessary functions of many signals, receptors and transcription factors have been demonstrated in mice, and mutations causing dental defects in humans have been identified in several genes. © 2006 Wiley‐Liss, Inc.